Dimethylformamide → HCID 178513017, compound

Participants

Reaction Steps

To a solution of 1H-pyrazole-1-carboximidamide hydrochloride (12 g, 82 mmol) and DMF (40 mL) at RT was added DIPEA (19 mL, 110 mmol) and 2-aminopropane-1,3-diol (5.0 g, 55 mmol) and the reaction was stirred overnight. Et2O (15 mL) was added and the reaction was stirred for 10 min before the reaction was allowed to settle and the ether layer was decanted. The remaining crude oil was concentrated under high vacuum to afford 7.3 g (100%) of 1-(1,3-dihydroxypropan-2-yl)guanidine (296) which contained residual DMF.

Provenance & Evidence