Methylamine → HCID 60198719, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 310 (0.059 g, 0.12 mmol) and THF (3 mL) was added methylamine (0.092 g, 1.2 mmol, 40% aqueous solution) and the reaction was stirred at 45° C. for 1 h. The solution was concentrated, poured into water and extracted with DCM. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH (500:30) to afford 3 mg (5.8%) of I-78: MS m/z (APCI-pos) M+1=435.

Provenance & Evidence