Acetone → HCID 86705532, compound

Participants

Reaction Steps

A mixture of (R)-2-bromo-1-(3-fluoro-4-(trifluoromethyl)phenyl)ethanol (3.0 g, 10 mmol), K2CO3 (2.9 g, 21 mmol) and acetone (50 mL) and was stirred for 18 h at RT, then poured in H2O and extracted with DCM. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with hexane/EtOAc (9:1) to afford 2.0 g (93%) of (R)-2-(3-fluoro-4-(trifluoromethyl)phenyl)oxirane (312).

Provenance & Evidence