Methanol → HCID 86705533, compound

Participants

Reaction Steps

To a solution of 312 (0.600 g, 2.91 mmol) and MeOH (1 mL) was added NaOMe (11.6 mL, 5.82 mmol) in MeOH and the reaction was stirred at RT for 3 d, then poured into water and extracted with DCM. The combined organic extractions were dried (MgSO4), filtered, and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH (500:10) to afford 0.630 g (90.9%) of (R)-1-(3-fluoro-4-(trifluoromethyl)phenyl)-2-methoxyethanol (314) which was contaminated with a small amount of the regioisomeric epoxide ring-opening product.

Provenance & Evidence