Methanesulfonyl chloride → HCID 86705550, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 174 (1.327 g, 4.144 mmol) in THF (30 mL) at 0° C. was added TEA (0.6931 mL, 4.973 mmol) and MsCl (0.3528 mL, 4.559 mmol) and the solution stirred for 1 h at 0° C. The mixture was diluted with EtOAc, washed with dilute HCl solution, aq. satd. NaHCO3, and brine, dried (MgSO4) and concentrated to afford 1.51 grams (91%) of (R)-3-(tert-butoxycarbonylamino)-3-(3,4-dichlorophenyl)propyl methanesulfonate (364). The product may contain some of the corresponding chloride.

Provenance & Evidence