Sodium Hydroxide → HCID 86705556, compound

Participants

Reaction Steps

To a stirred solution of 372 (660 mg, 1.88 mmol) in DCM (20 mL) at 0° C. was added MCPBA (1393 mg, 5.65 mmol) and stirring was continued at RT for 24 h. A dilute solution of NaOH was added and the mixture was twice extracted with DCM, washed with brine, dried (MgSO4), and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with 10% EtOAc/hexane to afford 609 mg (84%) of (R)-tert-butyl 1-(3,4-dichlorophenyl)-3-(methylsulfonyl)propylcarbamate (374) as a white solid.

Provenance & Evidence