Hydrochloric Acid → HCID 86705560, compound

Participants

Reaction Steps

To a stirred solution of 380 (8.98 g, 25.7 mmol) in MeOH (60 mL) and DCM (30 mL) was added 4M HCl in dioxane (12.9 mL, 51.4 mmol) and stirring was continued for 60 min at RT. HCl was removed with a stream of dry N2 and most of the solvent was removed on in a rotary evaporator. Ether was added to the residue and the precipitated white solid was filtered to afford 7.23 g (100%) of (R)-methyl 3-amino-3-(4-(difluoromethoxy)phenyl)propanoate hydrochloride (382) which was ca. 95% ee by chiral hplc.

Provenance & Evidence