HCID 86705570, compound → HCID 86705569, compound

Participants

Reaction Steps

tert-Butyl 3-phenyl-4-(2-(tetrahydro-2H-pyran-4-ylamino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-7-carbonyl)piperazine-1-carboxylate (0.0446 g, 0.0853 mmol) was dissolved in 3:1 DCM/TFA at 0° C. and then stirred for 45 minutes at room temperature. The solution was concentrated, 0.1 mL of 7N NH3/MeOH was added and the solution was concentrated. DCM was added and the solids were removed by filtration. The mother liquor was concentrated to provide (2-phenylpiperazin-1-yl)(2-(tetrahydro-2H-pyran-4-ylamino)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)methanone:MS m/z (APCI-pos) M+1=423.4.

Provenance & Evidence