2-Iodoxybenzoic acid → HCID 68295207, compound

Participants

Reaction Steps

To a solution of 414 (0.200 g, 0.603 mmol) and EtOAc (20 mL) was added 2-iodoxybenzoic acid (0.675 g, 2.41 mmol) and the resulting solution heated at reflux overnight. The reaction was cooled to RT and the white solid was filtered off and the filtrated was concentrated in vacuo to afford 0.16 g (80%) of tert-butyl 3-(4-chloro-3-fluorophenoxy)-4-oxo-pyrrolidine-1-carboxylate (416): LC-MS (ESI) m/z 274 (M+H-56).

Provenance & Evidence