Hydrochloric Acid → HCID 86705584, compound

Participants

Reaction Steps

To a solution of 418 (0.560 g, 1.69 mmol) and MeOH (10 mL) was added a methanolic HCl solution (4 N, 5 mL). The mixture was stirred at RT for 3 h and the solvent was removed in vacuo. The residue was neutralized with satd. aq. NaHCO3 (20 mL) and extracted with DCM/IPA (3:1, 3×100 mL) to afford 0.35 g (90%) of cis-(±)-4-(4-chloro-3-fluorophenoxy)pyrrolidin-3-ol (420) as a yellow oil.

Provenance & Evidence