反应详情

温度

90 °C

A mixture of ethyl 3-(difluoromethyl)-1-(5-fluoropyrimidin-2-yl)-1H-pyrazole-4-carboxylate (50 mg) and iodotrimethylsilane (1.0 mL) is heated at 90° C. for 4 h. The mixture is concentrated under vacuum, quenched with ice, and sodium metabisulfite is added until the aqueous solution becomes colorless. The mixture is then extracted with EtOAc (3×10 mL) and dried over anhydrous MgSO4. The dried extract is filtered and concentrated under vacuum to afford the title compound as white solid.

1. concentrationThe mixture is concentrated under vacuum
2. customquenched with ice, and sodium metabisulfite
3. additionis added until the aqueous solution
4. extractionThe mixture is then extracted with EtOAc (3×10 mL)
5. dry with materialdried over anhydrous MgSO4
6. extractionThe dried extract
7. filtrationis filtered
8. concentrationconcentrated under vacuum