HRID227962

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9995

Ethanamine, 2-fluoro-, hydrochloride (9CI)

C2H7ClFN

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CN(C(=O)OCc1ccccc1)C12CCC(C(=O)On3nnc4ccccc43)(CC1)CC2

HCID57756828

未命名化合物

PRODUCTS

生成物

结构：N#C[C@@H]1C[C@H](F)CN1C(=O)CN(C(=O)OCc1ccccc1)C12CCC(C(=O)NCCF)(CC1)CC2

HCID86616455

未命名化合物

收率 77.5%

PROCEDURE

实验过程

In a similar manner to Example 13, (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-(benzotriazol-1-yl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 2-fluoroethylamine hydrochloride (11.2 mg) were used to obtain (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-(N-2-fluoroethylamino)carbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (33.9 mg).