Diisopropylethylamine → HCID 59579828, compound

Participants

Reaction Steps

To a mixture of 3-amino-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylic acid (50 mg, 0.24 mmol) in 1.0 mL of DMF is added sequentially DIEA (0.08 mL, 0.48 mmol), 1-adamantan-1-ylmethan-amine (40 mg, 0.24 mmol), and BOP (128 mg, 0.29 mmol). The resulting mixture is stirred at RT for 18 h. Water (3 mL) is added, and the mixture is filtered. The solid is washed well with water and dried in vacuo to give the title compound as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ9.22 (1H, s), 8.75 (2H, s), 8.07 (1H, s), 7.33 (1H, s), 5.85 (2H, s), 2.90 (2H, d, J 5.2), 1.91 (3H, s), 1.61 (6H, m), 1.46 (6H, s). MS (M+1)=353.23; RT=1.31 min *IC50.

Provenance & Evidence