Diisopropylethylamine → HCID 59580012, compound

Participants

Reaction Steps

To a mixture of 3-chloro-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylic acid (50 mg, 0.22 mmol) in 1.0 mL of DMF is added sequentially DIEA (0.08 mL, 0.44 mmol), 1-{1-[4-(trifluoromethyl)-phenyl]cyclohexyl}methanamine (57 mg, 0.22 mmol), and BOP (115 mg, 0.26 mmol). The resulting mixture is stirred at RT for 20 h. Water (3 mL) is added, and the mixture is filtered. The solid is washed well with water and dried in vacuo to give the title compound as a white solid. 1H NMR (400 MHz, CDCl3) δ 9.09 (1H, s), 8.78 (2H, d, J 4.8), 7.65 (2H, d, J 8.4), 7.55 (2H, d, J 8.4), 7.31 (1H, t, J 4.8), 6.27 (1H, bs), 3.63 (2H, d, J 6), 2.17 (2H, m), 1.77 (2H, m), 1.66 (2H, m), 1.42 (4H, m). MS (M+1)=464.14; RT=1.37 min. *IC50.

Provenance & Evidence