Diisopropylethylamine → HCID 59579878, compound

Participants

Reaction Steps

To a mixture of 3-chloro-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylic acid (75 mg, 0.33 mmol) in 1.0 mL of DMF is added sequentially DIEA (0.11 mL, 0.66 mmol), 1-(1-pyridin-3-ylcyclohexyl)-methanamine (63 mg, 0.33 mmol), and BOP (177 mg, 0.40 mmol). The resulting mixture is stirred at RT for 20 h. Water (3 mL) is added, and the mixture is extracted with EtOAc (5 mL). The EtOAc layer is dried (Na2SO4), filtered, and evaporated in vacuo. The residue is purified by preparative chromatography (5% MeOH/CH2Cl2) to give the title compound as a white solid. 1H NMR (400 MHz, DMSO-d6) δ 9.17 (1H, s), 8.90 (2H, d, J 4.8), 8.58 (1H, s), 8.37 (1H, d, J 3.6), 8.05 (1H, s), 7.76 (1H, d, J 8.4), 7.56 (1H, t, J 4.8), 7.31 (1H, m), 2.16 (2H, m), 1.60 (4H, m), 1.43 (1H, m), 1.21 (5H, m). MS (M+1)=397.16; RT=1.07 min. *IC50.

Provenance & Evidence