1-Hydroxybenzotriazole → HCID 59579958, compound

Participants

Reaction Steps

BOP (35 mg, 0.08 mmol) is added to a solution of 1-pyrimidin-2-yl-3-trifluoromethyl-1H-pyrazol-4-ylamine (15 mg, 0.065 mmol), HOBt (5 mg), 1-adamantaneacetic acid (16 mg, 0.08 mmol) and DIEA (17 μL, 0.1 mmol) in DMF (0.5 mL) at RT. The mixture is stirred for 6 h. H2O is added to the mixture and is extracted with EtOAc (3×10 mL). The organic phase is dried. The crude material is purified by PTLC using 4% MeOH in CH2Cl2 to afford the title compound. 1H NMR (CDCl3): 9.38 (s, 1H), 8.6-81 (m, 2H), 7.30 (m, 1H), 2.16 (s, 2H), 2.01-1.97 (m, 3H), 1.80-1.50 (m, 12H). MS (M+1)=406.11; RT=1.4 min. *IC50.

Provenance & Evidence