Sodium Hydroxide → HCID 59580006, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (1.6 g) and sodium hydroxide (1.2 g) in MeOH (10 mL) and water (3 mL) is heated at 50° C. with stirring for 30 min, cooled and evaporated. The residue is acidified with citric acid solution and extracted with EtOAc six times. The combined extracts are washed once with brine, dried over Na2SO4 and concentrated to give the title compound as a solid.

Provenance & Evidence