HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → HCID 59579918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 59580006 | HCID 59580006 | — |
| Reactant | HCID 68735924 | HCID 68735924 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 59579918 | HCID 59579918 | — |
Reaction Steps
A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid (15 mg), 2-(4-chloro-phenyl)-4-methyl-pentylamine hydrochloride (14 mg), BOP (25 mg) and TEA (20 mg) in ACN (1 mL) is stirred at RT overnight. EtOAc and water added to the mixture and the organic layer is separated, washed twice with water and concentrated in vacuo. The residue is purified by PTLC (1:1 EtOAc/Hexane) to give the title compound. MS (M+1)=469.11; RT=1.36 min. *IC50.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133204B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5aa4899681f34d6aae5c86469b27f4df |
| Source note | uspto-grants-2015_09 |