HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2279656Generated: October 29, 2026
Sodium Hydroxide → N-Boc-amino-4-methylthiazole-5-carboxylic acid
https://huagongshe.com/reaction/2279656
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-[(tert-butoxycarbonyl)amino]-4-methyl-1,3-thiazole-5-carboxylate | HCID 53404548 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-Boc-amino-4-methylthiazole-5-carboxylic acid | HCID 2756770 | — |
Reaction Steps
A mixture of 2-tert-butoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid ethyl ester (4.3 g) and sodium hydroxide (10 N, 2.5 mL) in MeOH (80 mL) is heated at 50° C. overnight. The mixture is cooled, concentrated in vacuo, diluted with water and acidified to pH 4-5 with 2 N HCl. The solid is collected by filtration and dried to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09133204B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-723571fde6124a608edfdafd49910edb |
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| Source note | uspto-grants-2015_09 |
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