HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobicyclo[2.2.2]octan-1-ol → HCID 68844046, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobicyclo[2.2.2]octan-1-ol | HCID 12560134 | — |
| Reactant | (2S,4S)-1-[(N-benzyloxycarbonyl-N-[4-(benzotriazol-1-yl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57756828 | — |
| Product | HCID 68844046 | HCID 68844046 | 61.7% |
Reaction Steps
In a similar manner to Example 4, (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-(benzotriazol-1-yl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (50.0 mg) and 4-aminobicyclo[2.2.2]octane-1-ol (13.5 mg) were used to obtain (2S,4S)-1-[[N-benzyloxycarbonyl-N-[4-[N-(4-hydroxybicyclo[2.2.2]oct-1-yl)amino]carbonylbicyclo[2.2.2)oct-1-yl]amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (31.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560569B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-a40897f6dc92408dab3eda4117391dec |
| Source note | uspto-grants-2009_07 |