Methanol → HCID 10893325, compound

HRID 2279685Notes

Reaction equation

HRID 2279685 reaction equation
[CH2:1]([CH:9]1[O:11][CH:10]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH3:23][OH:24]>>[OH:11][CH:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH:10]([O:24][CH3:23])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 887MethanolHCID 5439232500-59-6

Product 1

HCID 10893325HCID 10893325, compound

Procedure

The methyl 8-(3-octyloxiran-2-yl)octanoate (2) (4.8 g; 0.015 mol), Amberlyst 15 (0.05 g) and methanol in excess (100 mL) were placed under reflux for 12 hours. The reaction mixture was filtered and the methanol removed using a rotary evaporator. The reaction mixture was dissolved in dichloromethane (100 mL) and washed with water (3×50 mL). The dichloromethane solution was separated and evaporated to obtain the intermediate compound 3.

Workup

  1. temperatureunder reflux for 12 hours
  2. filtrationThe reaction mixture was filtered
  3. customthe methanol removed
  4. customa rotary evaporator
  5. dissolutionThe reaction mixture was dissolved in dichloromethane (100 mL)
  6. washwashed with water (3×50 mL)
  7. customThe dichloromethane solution was separated
  8. customevaporated

Sources & evidence

ORD record
ord-63b76da5d46d458780dd1683e0c6a92a
Source dataset
uspto-grants-2015_09
Patent number
US09133305B2

Reaction notes

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