HRID2279708
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
This compound was prepared analogously to Compound 1B using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate (Compound 2C) and 7-amino-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-2,3-dihydro-1H-isoindol-1-one (Compound 1C) 1H NMR (400 MHz, CD3OD) δ 8.69 (br s, 1H), 8.32 (s, 1H), 8.04 (s, 1H), 7.89 (s, 1H), 7.68 (d, J=8.59 Hz, 1H), 7.57 (d, J=7.8 Hz, 2H), 7.34 (dd, J=2.4, 8.5 Hz, 2H), 4.55 (s, 2H), 4.31 (t, J=6.8 Hz, 2H), 4.01-4.12 (m, 4H), 3.57 (t, J=6.1 Hz, 2H), 3.29 (d, J=20.7 Hz, 2H), 3.17 (s, 3H), 2.10 (quin, J=6.5 Hz, 2H), 1.26 (t, J=7.1 Hz, 6H). MS (ES+): m/z 674.21 [M+H]+. UPLC: tR=1.33 min (UPLC-TOF: polar—3 min).
WORKUP
后处理
- customtR=1.33 min (UPLC-TOF: polar—3 min)