Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → Diethyl (4-{[4-({2-(dimethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

HRID 2279740Notes

Reaction equation

HRID 2279740 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([NH:21][C:22]3[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][N:25]=[C:24]([NH:32][C:33]4[CH:47]=[CH:46][C:36]([CH2:37][P:38](=[O:45])([O:42][CH2:43][CH3:44])[O:39][CH2:40][CH3:41])=[CH:35][C:34]=4OC)[N:23]=3)=[C:14]3[C:18]=2[CH2:17][N:16]([CH3:19])[C:15]3=[O:20])[CH:7]=[N:6]1.NC1C=CC(C2C=NN(CCCO)C=2)=CC=1C(N(C)C)=O>>[CH3:19][N:16]([CH3:17])[C:15]([C:14]1[CH:18]=[C:10]([C:8]2[CH:7]=[N:6][N:5]([CH2:4][CH2:3][CH2:2][OH:1])[CH:9]=2)[CH:11]=[CH:12][C:13]=1[NH:21][C:22]1[C:27]([C:28]([F:29])([F:31])[F:30])=[CH:26][N:25]=[C:24]([NH:32][C:33]2[CH:34]=[CH:35][C:36]([CH2:37][P:38](=[O:45])([O:39][CH2:40][CH3:41])[O:42][CH2:43][CH3:44])=[CH:46][CH:47]=2)[N:23]=1)=[O:20]

Participants

3

Reactant 2

HCID 58292892Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonateHCID 678148032-Amino-5-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-N,N-dimethylbenzamide2×

Product 1

HCID 86697696Diethyl (4-{[4-({2-(dimethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonateYield 22%

Procedure

Prepared analogously to Compound 1B replacing Compound 1C with 2-Amino-5-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-N,N-dimethylbenzamide (Compound 11C, 506 mg, 1.19 mmol) to afford 177 mg of the title compound (22%). 1H NMR (400 MHz, CD3OD) δ 8.29 (s, 1H), 8.16 (s, 1H), 7.97 (s, 1H), 7.71-7.79 (m, 2H), 7.62 (d, J=1.8 Hz, 1H), 7.40 (d, J=7.8 Hz, 2H), 7.12 (d, J=5.6 Hz, 2H), 4.32 (t, J=6.9 Hz, 2H), 3.91-4.04 (m, 4H), 3.55-3.61 (m, 2H), 3.07-3.16 (d, J=21 Hz, 2H), 3.04 (s, 3H), 2.91 (s, 3H), 2.10 (t, J=6.4 Hz, 2H), 1.21 (t, J=7.1 Hz, 6H). MS (ESI): m/z 676.77 [M+H]+. UPLC: tR=1.07 min (UPLC-SQD: analytical—2 min).

Sources & evidence

ORD record
ord-0c81bdcb50c94942adb854e21e137af4
Source dataset
uspto-grants-2015_09
Patent number
US09133224B2

Reaction notes

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