Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 86697705, compound

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Prepared analogously to Compound 3A using (4-{[4-({6-[1-(4-hydroxybutyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate (Compound 16B, 127 mg, 188 μmol) to afford 109 mg of the title compound (90%). 1H NMR (400 MHz, CD3OD) δ 9.16 (br. s., 1H), 8.44 (br. s., 1H), 8.28 (s, 1H), 8.15-8.19 (m, 1H), 7.67 (d, J=8.8 Hz, 1H), 7.44 (dd, J=2.6, 7.9 Hz, 2H), 7.33 (dd, J=1.9, 8.5 Hz, 2H), 4.22 (t, J=7.1 Hz, 2H), 3.86 (quin, J=7.0 Hz, 2H), 3.57-3.63 (m, 2H), 3.03 (s, 1H), 2.94-3.00 (m, 4H), 1.92-2.05 (m, 2H), 1.50-1.64 (m, 2H), 1.16 (t, J=7.1 Hz, 3H). MS (ESI): m/z 649.75 [M+H]+. UPLC: tR=1.10 min (UPLC-SQD: analytical—2 min).

Provenance & Evidence