Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → Ethyl hydrogen (4-{[4-({6-[1-(3-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

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Prepared analogously to Compound 3A using diethyl (4-{[4-({6-[1-(3-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 18B): 1H NMR (CD3OD, 400 MHz): δ=9.02 (br. s., 1H), 8.52 (s, 1H), 8.32 (s, 1H), 8.25 (s, 1H), 7.75 (d, J=8.8 Hz, 1H), 7.64 (br. s., 1H), 7.12 (s, 1H), 6.98-6.92 (m, 1H), 4.29 (dd, J=6.7, 13.5 Hz, 1H), 4.08 (dd, J=7.1, 13.6 Hz, 1H), 3.92-3.83 (m, 5H), 3.48 (d, J=5.8 Hz, 2H), 3.03 (d, J=21.0 Hz, 2H), 2.99 (s, 3H), 2.33-2.23 (m, 1H), 1.15 (t, J=7.1 Hz, 3H), 0.95 (d, J=7.1 Hz, 3H). MS (ESI): m/z=679.75 [M+H]+. UPLC: tR=1.16 min (UPLC-SQD: analytical—2 min).

Provenance & Evidence