Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 86697712, compound

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Prepared analogously to Compound 1B using replacing compound 1C with 3-amino-6-[1-(3-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]-N-methylpyridine-2-carboxamide (Compound 18C). 1H NMR (CD3OD, 400 MHz): δ=8.92 (br. s., 1H) 8.51 (s, 1H) 8.37 (br. s., 1H) 8.31 (s, 1H) 7.77 (d, J=8.8 Hz, 1H) 7.54 (d, J=7.8 Hz, 1H) 7.17 (s, 1H) 7.04 (d, J=7.8 Hz, 1H) 4.29 (dd, J=13.8, 6.44 Hz, 1H) 4.00-4.16 (m, 5H) 3.89 (s, 3H) 3.47 (d, J=5.6 Hz, 2H) 3.37 (d, J=21.7 Hz, 2H) 3.00 (s, 3H) 2.26 (dq, J=12.8, 6.4 Hz, 1H) 1.27 (t, J=7.1 Hz, 6H) 0.94 (d, J=6.8 Hz, 3H). MS (ESI): m/z=707.70 [M+H]+. UPLC: tR=1.29 min (UPLC-SQD: analytical—2 min).

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