3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol → HCID 67813904, compound

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Reaction Steps

Prepared analogously to Compound 3E using 1-[3-(Benzyloxy)-2-methylpropyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole to afford 376 mg of the title compound (91%). 1H NMR (CDCl3, 400 MHz): δ=7.81 (s, 1H) 7.70 (s, 1H) 4.22-4.29 (m, 1H) 4.13-4.20 (m, 1H) 3.51-3.55 (m, 1H) 3.50 (s, 1H) 3.36 (dd, J=11.37, 6.57 Hz, 1H) 2.16-2.26 (m, 1H) 1.33 (s, 12H) 0.93 (d, J=6.82 Hz, 3H). MS (ESI): m/z=267.18 [M+H]+. UPLC: tR=1.18 min (UPLC-TOF: polar—3 min).

Provenance & Evidence