Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → diethyl (3-fluoro-4-{[4-({6-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

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Prepared analogously to Compound 1B replacing compound 1C with Compound 6C (278 mg, 1.01 mmol) and Compound 1 E with diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-fluorobenzyl)phosphonate (Compound 22C, 446 mg, 1.01 mmol) to afford 157 mg of the title compound (23%). 1H NMR (400 MHz, CD3OD) δ=8.61-8.86 (m, 1H), 8.56 (s, 1H), 8.43 (br. s., 1H), 8.35 (s, 1H), 7.76 (d, J=8.8 Hz, 1H), 7.55 (t, J=8.0 Hz, 1H), 7.37 (dd, J=2.2, 11.0 Hz, 1H), 7.32 (d, J=8.3 Hz, 1H), 4.32 (t, J=7.0 Hz, 2H), 4.12 (quin, J=7.3 Hz, 4H), 3.57 (t, J=6.1 Hz, 2H), 3.42 (d, J=21.0 Hz, 2H), 3.00 (s, 3H), 2.11 (quin, J=6.5 Hz, 2H), 1.17-1.34 (m, 6H). MS (ESI): m/z=681.74 [M+H]+. UPLC: tR=1.20 min (UPLC-SQD: analytical—2 min).

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