Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 86697721, compound

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Prepared analogously to Compound 3A using diethyl (3-fluoro-4-{[4-({6-[1-(4-hydroxybutyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate (Compound 23B, 133 mg, 191 μmol) to afford 115 mg of the title compound (90%). 1H NMR (400 MHz, CD3OD) δ=8.98-9.08 (m, 1H), 8.56 (s, 1H), 8.32 (s, 1H), 8.23 (s, 1H), 7.71 (d, J=8.8 Hz, 1H), 7.51 (t, J=7.8 Hz, 1H), 7.26 (d, J=11.9 Hz, 1H), 7.18 (d, J=8.1 Hz, 1H), 4.24 (t, J=7.1 Hz, 2H), 3.88 (quin, J=7.0 Hz, 2H), 3.60 (t, J=6.4 Hz, 2H), 3.01-3.10 (m, 2H), 2.96-3.00 (m, 3H), 1.93-2.03 (m, 2H), 1.50-2.06 (m, 2H), 1.14 (t, J=7.07 Hz, 3H). MS (ESI): m/z=667.69 [M+H]+. UPLC: tR=1.13 min (UPLC-SQD: analytical—2 min).

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