Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → HCID 86697726, compound

Participants

Role	Name	HCID	Charge
Reactant	Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate	HCID 86697678	—
Reactant	HCID 86697727	HCID 86697727	—
Product	HCID 86697726	HCID 86697726	99%

Reaction Steps

Prepared analogously to Compound 3A using diethyl (4-{[4-({4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methoxycarbamoyl)phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 26B, 114 mg, 161 μmol) to afford 108 mg of the title compound (99%). MS (ESI): m/z=680.75 [M+H]+. UPLC: tR=1.02 min (UPLC-SQD: analytical—2 min).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09133224B2
Source dataset	uspto-grants-2015_09
ORD ID	ord-dd0b6d8f4374420f9199cd4b725a077a
Source note	uspto-grants-2015_09