HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-amino-5-bromo-N-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 2-Amino-5-bromo-N,N-diethylbenzamide | HCID 50999513 | — |
| Product | 2-amino-5-bromo-N-methoxybenzamide | HCID 81679180 | 65% |
Reaction Steps
Prepared analogously to Compound 3D replacing diethylamine with a mixture of methoxylamine hydrochloride (2.07 g, 24.8 mmol) and triethylamine (6.9 mL, 50 mmol) to afford 2.64 g of the title compound (65%). 1H NMR (400 MHz, CD3OD) δ=7.45 (d, J=2.3 Hz, 1H), 7.27 (dd, J=2.3, 8.8 Hz, 1H), 6.69 (d, J=8.8 Hz, 1H), 3.77 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6044e20198634c8788a84e2419051720 |
| Source note | uspto-grants-2015_09 |