HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione → 6-amino-3-bromo-2-chloro-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 639058 | — |
| Reactant | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| Reactant | 6-amino-3-bromo-2-fluoro-N-methylbenzamide | HCID 86697732 | — |
| Product | 6-amino-3-bromo-2-chloro-N-methylbenzamide | HCID 86697736 | — |
Reaction Steps
Prepared analogously to Compound 27D replacing 5-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione (Compound 27E) with 5-Chloro-1H-benzo[d][1,3]oxazine-2,4-dione (Compound 28E). 1H NMR (CDCl3, 500 MHz) δ=2.95 (d, J=5.2 Hz, 3H), 6.02 (brs, 2H), 6.89 (d, J=8.8 Hz, 1H), 7.25 (d, J=8.8 Hz, 1H), 7.79 (brs, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-3d59b41ad3094b139e8589a573d6f5ed |
| Source note | uspto-grants-2015_09 |