HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoroisatoic anhydride → 6-amino-3-bromo-2-methyl-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| Reactant | 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10487522 | — |
| Reactant | 6-amino-3-bromo-2-fluoro-N-methylbenzamide | HCID 86697732 | — |
| Product | 6-amino-3-bromo-2-methyl-N-methylbenzamide | HCID 86697739 | — |
Reaction Steps
Prepared analogously to Compound 27D replacing 5-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione (Compound 27E) with 5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione (Compound 29E). 1H NMR (CDCl3, 500 MHz) δ 2.32 (s, 3H), 2.98 (d, J=4.8 Hz, 3H), 4.0 (br.s, 2H), 5.81 (br.s, 1H), 6.42 (d, J=8.8 Hz, 1H), 7.27 (d, J=8.8 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fa3f372511e04ac7807fab5d79d50367 |
| Source note | uspto-grants-2015_09 |