HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methylanthranilic acid → 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methylanthranilic acid | HCID 151210 | — |
| Reactant | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| Product | 5-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 10487522 | — |
Reaction Steps
Prepared analogously to Compound 27E replacing 2-amino-6-fluorobenzoic acid with 2-amino-6-methylbenzoic acid. 1H NMR (DMSO-d6, 500 MHz) δ 2.32 (s, 3H), 7.09 (m, 1H), 7.21-7.25 (m, 1H), 7.51-7.61 (m, 1H), 11.65 (br.s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-456ba860b5804d6b8bd12537ae2911f4 |
| Source note | uspto-grants-2015_09 |