HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromo-N,N-diethylbenzamide → 6-amino-3-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methoxy-N-methyl benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromo-N,N-diethylbenzamide | HCID 50999513 | — |
| Reactant | 2-amino-N,N-diethyl-5-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]benzamide | HCID 86697680 | — |
| Reactant | 6-Amino-3-bromo-2-methoxy-N-methylbenzamide | HCID 86697742 | — |
| Product | 6-amino-3-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methoxy-N-methyl benzamide | HCID 67816787 | — |
Reaction Steps
Prepared analogously to Compound 3C substituting 6-amino-3-bromo-2-methoxy-N-methylbenzamide (Compound 30D) for 2-amino-5-bromo-N,N-diethylbenzamide (Compound 3D). MS (ESI): m/z=305.23 [M+H]+. HPLC: tR=2.48 min (ZQ3: polar—5 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133224B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-ea70de8710864cfd87bc08d5271d4652 |
| Source note | uspto-grants-2015_09 |