反应详情

This material was prepared analogously to compound 1B using 3-Amino-6-bromo-N-methoxypyridine-2-carboxamide (Compound 46D, 302.0 mg, 1.227 mmol) and diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 1 E, 612.6 mg, 1.350 mmol) to isolate 189 mg of the title compound (23%). 1H NMR (400 MHz, DMSO-d6) δ 12.18 (s, 1H), 11.88 (s, 1H), 9.21 (br. s., 1H), 8.87 (br. s., 1H), 8.44 (s, 1H), 7.65 (d, J=8.8 Hz, 1H), 7.38 (br. s., 1H), 7.06 (s, 1H), 6.90 (d, J=8.1 Hz, 1H), 3.96-4.05 (m, 4H), 3.74 (s, 3H), 3.70 (s, 3H), 3.29 (d, J=21.2 Hz, 2H), 1.20 (t, J=7.0 Hz, 6H)