HRID2279848
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Prepared analogously to Compound 1B using diethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 1 E, 304 mg, 0.671 mmol) and 2-amino-5-[1-(4-hydroxy-2-methylbutan-2-yl)-1H-pyrazol-4-yl]-N-methylbenzamide (Compound 50C, 213.1 mg, 0.705 mmol) to afford 117 mg of the title compound (24%). 1H NMR (400 MHz, CD3OD) δ 9.01 (d, J=8.8 Hz, 1H), 8.62 (s, 1H), 8.34 (s, 1H), 8.27 (s, 1H), 7.70-7.76 (m, 2H), 7.07 (s, 1H), 6.96 (dd, J=2.3, 10.6 Hz, 1H), 4.01-4.12 (m, 5H), 3.88 (s, 3H), 3.42 (t, J=7.1 Hz, 2H), 2.99 (s, 3H), 2.14-2.24 (m, 3H), 1.70 (s, 6H), 1.21-1.30 (m, 6H). MS (ESI): m/z=721.49 [M+H]+. UPLC: tR=1.33 min (UPLC-TOF: polar—2 min).