HRID2279870
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
Prepared analogously to Compound 38C replacing Compound 38B with diethyl (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2-chloro-5-methoxybenzyl)phosphonate (Compound 56C). 1H NMR (400 MHz, DMSO-d6) δ=12.39 (br. s., 1H), 9.18 (br. s., 1H), 8.91-8.99 (m, 1H), 8.49 (s, 1H), 7.71 (d, J=9.1 Hz, 1H), 7.64 (br. s., 1H), 7.16 (d, J=2.0 Hz, 1H), 3.95 (quin, J=7.3 Hz, 2H), 3.77 (s, 3H), 3.22-3.27 (m, 2H), 2.81 (d, J=5.1 Hz, 3H), 1.18 (t, J=6.9 Hz, 3H). MS (ESI): m/z 653.02/655.02 [M+H]+. UPLC: tR=0.89 min (polar—2 min).
WORKUP
后处理
- customtR=0.89 min (polar—2 min)