反应详情

This material was prepared analogously to Compound 61A using (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)methylphosphinic acid (Compound 61B, 250 mg, 0.42 mmol) and 2,2-dimethyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol (Compound 47B, 119 mg, 0.424 mmol) to afford 70 mg of the title compound (19%). MS (ESI): m/z=851.22/853.23 [M+H]+. UPLC: tR=1.17 min (UPLC-TOF: polar—2 min).