反应详情

温度

50 °C

A solution of −({1-[(benzyloxy)methyl]cyclopropyl}methyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (Compound 63C, 8 g, 21.7 mmol) in ethanol (100 mL) was treated with palladium on charcoal (10%, 6 g) and heated to 50° C. under hydrogen atmosphere for 24 hrs. The catalyst was filtered off and the filtrate was concentrated to a residue under reduced pressure. The residue was triturated with isopropyl ether to give 3.2 g (53%) of the required material as white solid. 1H NMR (500 MHz, CDCl3) δ 7.81 (s, 1H), 7.7 (s, 1H), 4.14 (s, 2H), 3.38 (s, 2H), 1.33 (s, 12H), 0.54-0.65 (m, 4H).

1. filtrationThe catalyst was filtered off
2. concentrationthe filtrate was concentrated to a residue under reduced pressure
3. customThe residue was triturated with isopropyl ether