Diisopropylethylamine → ethyl 3-[4-(tributylstannanyl)-1H-1,2,3-triazol-1-yl]propyl (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Participants

Reaction Steps

To a solution of ethyl hydrogen (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 38C, 205 mg, 0.331 mmol), 3-[4-(tributylstannanyl)-1H-1,2,3-triazol-1-yl]propan-1-ol (Compound 64B, 165 mg, 0.397 mmol) and DIPEA (0.17 mL, 0.993 mmol) in 1,2-dichloroethane (8 mL) was added (benzotriazol-1-yloxy)tripyrrolidino-phosphonium hexafluorophosphate (517 mg, 0.993 mmol). The resulting mixture was stirred at rt overnight. The mixture was diluted with DCM (30 mL), washed with sat. aq. NaHCO3 (2×20 mL), brine (20 mL), and dried over anhydrous sodium sulfate. The solvents were evaporated under reduced pressure, and the residue was purified by silica gel chromatography (ISCO system: MeOH/DCM=0-3%) to give the desired product, which was used in the following step. MS (ESI): m/z 1018.86 [M+H]+. UPLC: tR=1.22 min (UPLC-SQD: very non-polar—2 min).

Provenance & Evidence