3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol → HCID 178485573, compound

Participants

Reaction Steps

This material was prepared analogously to Example 44A using (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)ethylphosphinic acid (Compound 67B, 0.220 g, 0.365 mmol) and 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol (Compound 3E, 0.0918 g, 0.364 mmol) to afford the title compound as an off-white foam (275 mg, 90%). MS (ESI): m/z 837.21/839.20 [M+H]+. UPLC: tR=1.14 min (UPLC-TOF: polar—2 min).

Provenance & Evidence