huagongshe.com
HRID2279911

反应详情

EQUATION

反应方程式

HRID 2279911 的结构方程式

REACTANTS

反应物

3
结构：CC1(C)OB(c2cnn(CC3(CO)CC3)c2)OC1(C)C
HCID67811260

未命名化合物

2 次

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(Br)nc3C(=O)NC)n2)c(OC)c1)O[C@H](C)CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID86697847

未命名化合物

结构：CNC(=O)c1nc(Br)ccc1Nc1nc(Nc2ccc(CCC[PH](=O)O)cc2OC)ncc1C(F)(F)F
HCID178485570

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CNC(=O)c1nc(Br)ccc1Nc1nc(Nc2ccc(CCC[PH](=O)OCC3(Cn4cc(B5OC(C)(C)C(C)(C)O5)cn4)CC3)cc2OC)ncc1C(F)(F)F
HCID178485571

未命名化合物

收率 48%

PROCEDURE

实验过程

Racemic Compound 71A was prepared analogously to Compound 69A using (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)ethylphosphinic acid (Compound 67B, 206 mg, 0.341 mmol) and (1-{[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}cyclopropyl)methanol (Compound 63B, 400 mg, 2 mmol) to afford 129 mg of the title compound (48%). MS (ESI): m/z=879.92/881.81 [M+H]+. UPLC: tR=1.61 min (UPLC-TOF: polar—2 min).