HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2279913Generated: October 29, 2026
Sodium Iodide → Propan-2-yl hydrogen (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
https://huagongshe.com/reaction/2279913
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Ethyl propan-2-yl (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate | HCID 86697852 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Propan-2-yl hydrogen (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate | HCID 86697851 | — |
Reaction Steps
A solution of ethyl propan-2-yl (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 72C, 550.0 mg, 0.83 mmol) in pyridine (5.50 mL) was charged with sodium iodide (748 mg, 4.99 mmol). The reaction was heated at 120° C. for 24 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09133224B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-32d62d88558643a0b40983059cb6725c |
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| Source note | uspto-grants-2015_09 |
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