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HRID2279916

反应详情

EQUATION

反应方程式

HRID 2279916 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(CO)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID67812442

未命名化合物

2 次

结构：CCOP(=O)(Cc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(Br)nc3C(=O)NC)n2)c(OC)c1)O[C@H](C)CCn1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID86697847

未命名化合物

结构：CNC(=O)c1nc(Br)ccc1Nc1nc(Nc2ccc(CP(=O)(O)OC(C)C)cc2OC)ncc1C(F)(F)F
HCID86697851

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CNC(=O)c1nc(Br)ccc1Nc1nc(Nc2ccc(CP(=O)(OCC(C)(C)Cn3cc(B4OC(C)(C)C(C)(C)O4)cn3)OC(C)C)cc2OC)ncc1C(F)(F)F
HCID86697856

未命名化合物

收率 40%

PROCEDURE

实验过程

Racemic Compound 73A was prepared analogously to Compound 69A by using propan-2-yl hydrogen (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate (Compound 72B, 265 mg, 0.418 mmol) and 2,2-dimethyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-1-ol (Compound 47B, 117 mg, 0.418 mmol) to afford 149 mg of the title compound (40%). MS (ESI): m/z=895.81/897.83 [M+H]+. UPLC: tR=1.77 min (UPLC-TOF: polar—2 min).