HCID 178476807, compound → HCID 178485566, compound

HRID 2279918Notes

Reaction equation

HRID 2279918 reaction equation
BrC1N=C(C(=O)NC)C(NC2C(C(F)(F)F)=CN=C(NC3C=CC(CCCP(=O)O)=CC=3OC)N=2)=CC=1.[Br:38][C:39]1[N:44]=[C:43]([C:45](=[O:48])[NH:46][CH3:47])[C:42]([NH:49][C:50]2[C:55]([C:56]([F:59])([F:58])[F:57])=[CH:54][N:53]=[C:52]([NH:60][C:61]3[CH:75]=[CH:74][C:64]([CH2:65][CH2:66][CH2:67][CH2:68][PH:69](=[O:73])[O:70]CC)=[CH:63][C:62]=3[O:76][CH3:77])[N:51]=2)=[CH:41][CH:40]=1>>[Br:38][C:39]1[N:44]=[C:43]([C:45](=[O:48])[NH:46][CH3:47])[C:42]([NH:49][C:50]2[C:55]([C:56]([F:59])([F:57])[F:58])=[CH:54][N:53]=[C:52]([NH:60][C:61]3[CH:75]=[CH:74][C:64]([CH2:65][CH2:66][CH2:67][CH2:68][PH:69](=[O:70])[OH:73])=[CH:63][C:62]=3[O:76][CH3:77])[N:51]=2)=[CH:41][CH:40]=1

Participants

3

Reactant 2

HCID 178476807HCID 178476807, compound2×HCID 178485570HCID 178485570, compound

Product 1

HCID 178485566HCID 178485566, compound

Procedure

Prepared analogously to Compound 67B replacing Compound 67C with ethyl (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)propylphosphinate (Compound 74C). MS (ESI): m/z 617.55/619.52 [M+H]+. UPLC: tR=1.31 min (UPLC-SQD: analytical—2 min).

Workup

  1. customtR=1.31 min (UPLC-SQD: analytical—2 min)

Sources & evidence

ORD record
ord-ccc0bd63f4a844d598ca630bf62085f0
Source dataset
uspto-grants-2015_09
Patent number
US09133224B2

Reaction notes

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