反应详情

Prepared analogously to Compound 1B replacing Compound 1C with compound 6D and Compound 1 E with ethyl (4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)propylphosphinate (Compound 37C). 1H NMR (CDCl3, 400 MHz): δ 12.25 (s, 1H), 9.05 (d, J=8.8 Hz, 1H), 8.43 (s, 1H), 8.10 (d, J=4.8 Hz, 2H), 7.69 (br. s., 1H), 7.51 (d, J=8.8 Hz, 1H), 6.94 (t, J=1.8 Hz, 1H), 6.82 (td, J=1.8, 8.2 Hz, 1H), 3.98-4.13 (m, 2H), 3.92 (s, 3H), 3.13 (d, J=16.4 Hz, 2H), 3.05 (d, J=5.3 Hz, 3H), 1.62-1.68 (m, 4H), 1.31 (t, J=7.1 Hz, 3H), 0.98-1.04 (m, 3H). MS (ESI): m/z 645.62/647.56 [M+H]+. UPLC: tR=1.47 min (UPLC-SQD: analytical—2 min).

1. customtR=1.47 min (UPLC-SQD: analytical—2 min)