HCID 178485568, compound → HCID 178485572, compound

HRID 2279920Notes

Reaction equation

HRID 2279920 reaction equation
BrC1N=C(C(=O)NC)C(NC2C(C(F)(F)F)=CN=C(NC3C=CC(CCCCP(=O)O[CH2:34][C:35]([CH3:52])([CH3:51])[CH2:36][N:37]4[CH:41]=[C:40]([B:42]5[O:46][C:45]([CH3:48])([CH3:47])[C:44]([CH3:50])([CH3:49])[O:43]5)[CH:39]=[N:38]4)=CC=3OC)N=2)=CC=1.[Br:58][C:59]1[N:64]=[C:63]([C:65](=[O:68])[NH:66][CH3:67])[C:62]([NH:69][C:70]2[C:75]([C:76]([F:79])([F:78])[F:77])=[CH:74][N:73]=[C:72]([NH:80][C:81]3[CH:92]=[CH:91][C:84]([CH2:85][CH2:86][CH2:87][PH:88](=[O:90])[OH:89])=[CH:83][C:82]=3[O:93][CH3:94])[N:71]=2)=[CH:61][CH:60]=1>>[Br:58][C:59]1[N:64]=[C:63]([C:65](=[O:68])[NH:66][CH3:67])[C:62]([NH:69][C:70]2[C:75]([C:76]([F:79])([F:77])[F:78])=[CH:74][N:73]=[C:72]([NH:80][C:81]3[CH:92]=[CH:91][C:84]([CH2:85][CH2:86][CH2:87][PH:88](=[O:89])[O:90][CH2:34][C:35]([CH3:52])([CH3:51])[CH2:36][N:37]4[CH:41]=[C:40]([B:42]5[O:46][C:45]([CH3:48])([CH3:47])[C:44]([CH3:50])([CH3:49])[O:43]5)[CH:39]=[N:38]4)=[CH:83][C:82]=3[O:93][CH3:94])[N:71]=2)=[CH:61][CH:60]=1

Participants

3

Reactant 2

HCID 178485568HCID 178485568, compoundHCID 178485570HCID 178485570, compound2×

Product 1

HCID 178485572HCID 178485572, compound

Procedure

Prepared analogously to Compound 74A replacing Compound 74B with (4-{[4-{[6-bromo-2-(methylcarbamoyl)pyridin-3-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)ethylphosphinic acid (Compound 67B). MS (ESI): m/z 865.86/867.92 [M+H]+. UPLC: tR=1.61 min (UPLC-SQD: analytical—2 min).

Workup

  1. customtR=1.61 min (UPLC-SQD: analytical—2 min)

Sources & evidence

ORD record
ord-1de75a7421794dbf8353834e09545f14
Source dataset
uspto-grants-2015_09
Patent number
US09133224B2

Reaction notes

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