Hydrochloric Acid → HCID 68712100, compound

Participants

Reaction Steps

To a stirred solution of 2-amino-2-(3-(benzyloxy)phenyl)acetonitrile (1.22 g, 5.3 mmol) in methanol (10 mL) at room temperature was added 2 N HCl in ether (10 mL, 20 mmol). The resulting mixture was heated under reflux for 18 h and concentrated to dryness. The crude material was taken up in ethyl acetate (200 mL) and washed with saturated aqueous sodium bicarbonate (100 mL). The layers were separated and the organic phase dried over magnesium sulfate, filtered and the solvent was removed in vacuo. The residue was loaded onto a SCX cartridge eluting with dichloromethane/methanol followed by 7N ammonia in methanol to afford the title compound (1.0 g, 70%) as a thick orange oil.

Provenance & Evidence