Lithium Hydroxide → HCID 118116930, compound

Participants

Reaction Steps

A solution of methyl 2-(benzyloxycarbonylamino)-2-(3-benzyloxyphenyl)acetate (640 mg, 1.75 mmol) and aqueous lithium hydroxide (1 N, 3.50 mL, 3.50 mmol) in methanol (5 mL) and tetrahydrofuran (5 mL) was stirred at room temperature for one hour. The mixture was concentrated in vacuo and the residue diluted with dichloromethane (30 mL) and acidified to pH 0.5 with 2 N HCl. The aqueous phase was re-extracted with dichloromethane (2×50 mL). The combined organic fractions were dried over a hydrophobic frit and the solvent was removed in vacuo to give the title compound as a light brown oil (460 mg, 67%). This was used in the next step without further purification.

Provenance & Evidence